Identification of hit compounds with anti-schistosomal activity on in vitro generated juvenile worms in cell-free medium.

• Main Authors: Nermina Vejzagić (Author), Ulrich Fabien Prodjinotho (Author), Nagwa El-Khafif (Author), Ruili Huang (Author), Anton Simeonov (Author), Thomas Spangenberg (Author), Clarissa Prazeres da Costa (Author)
• Formato: Livro
• Publicado em: Public Library of Science (PLoS), 2021-05-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

<h4>Background</h4>Anthelminthic treatment options against schistosomiasis are limited. The current treatment relies almost exclusively on a single drug, praziquantel (PZQ). As a consequence, the development of resistance to PZQ and limited activity of PZQ against earlier development sta...