Antigenicity and diagnostic potential of vaccine candidates in human Chagas disease.

• Main Authors: Shivali Gupta (Author), Xianxiu Wan (Author), Maria P Zago (Author), Valena C Martinez Sellers (Author), Trevor S Silva (Author), Dadjah Assiah (Author), Monisha Dhiman (Author), Sonia Nuñez (Author), John R Petersen (Author), Juan C Vázquez-Chagoyán (Author), Jose G Estrada-Franco (Author), Nisha Jain Garg (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2013-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Chagas disease, caused by Trypanosoma cruzi, is endemic in Latin America and an emerging infectious disease in the US and Europe. We have shown TcG1, TcG2, and TcG4 antigens elicit protective immunity to T. cruzi in mice and dogs. Herein, we investigated antigenicity of the recombinant proteins in h...