Role of Caspase-12 in Amyloid β-Peptide-Induced Toxicity in Organotypic Hippocampal Slices Cultured for Long Periods

• Main Authors: Kumiko Ishige (Author), Noritaka Takagi (Author), Toru Imai (Author), Wolf Dieter Rausch (Author), Yasuhiro Kosuge (Author), Tetsuroh Kihara (Author), Kuniko Kusama-Eguchi (Author), Hiroko Ikeda (Author), Alexander Rudolf Cools (Author), John Lionel Waddington (Author), Noriaki Koshikawa (Author), Yoshihisa Ito (Author)
• Format: Book
• Published: Elsevier, 2007-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Amyloid β (Aβ) toxicity has been implicated in cell death in the hippocampus, but its specific mechanisms are poorly understood. In this study, Aβ-induced cell death was investigated in organotypic hippocampal slice cultures (OHCs) that were cultured for various periods in vitro. There were no obvio...