IL-7 Induces an Epitope Masking of γc Protein in IL-7 Receptor Signaling Complex

• Main Authors: Tae Sik Goh (Author), Yuna Jo (Author), Byunghyuk Lee (Author), Geona Kim (Author), Hyunju Hwang (Author), Eunhee Ko (Author), Seung Wan Kang (Author), Sae-Ock Oh (Author), Sun-Yong Baek (Author), Sik Yoon (Author), Jung Sub Lee (Author), Changwan Hong (Author)
• Format: Book
• Published: Hindawi Limited, 2017-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

IL-7 signaling via IL-7Rα and common γ-chain (γc) is necessary for the development and homeostasis of T cells. Although the delicate mechanism in which IL-7Rα downregulation allows the homeostasis of T cell with limited IL-7 has been well known, the exact mechanism behind the interaction between IL-...