IL-7 Induces an Epitope Masking of γc Protein in IL-7 Receptor Signaling Complex

• Główni autorzy: Tae Sik Goh (Autor), Yuna Jo (Autor), Byunghyuk Lee (Autor), Geona Kim (Autor), Hyunju Hwang (Autor), Eunhee Ko (Autor), Seung Wan Kang (Autor), Sae-Ock Oh (Autor), Sun-Yong Baek (Autor), Sik Yoon (Autor), Jung Sub Lee (Autor), Changwan Hong (Autor)
• Format: Książka
• Wydane: Hindawi Limited, 2017-01-01T00:00:00Z.
• Hasła przedmiotowe: article
• Dostęp online: Connect to this object online.

IL-7 signaling via IL-7Rα and common γ-chain (γc) is necessary for the development and homeostasis of T cells. Although the delicate mechanism in which IL-7Rα downregulation allows the homeostasis of T cell with limited IL-7 has been well known, the exact mechanism behind the interaction between IL-...