Characterization of the Burkholderia mallei tonB Mutant and Its Potential as a Backbone Strain for Vaccine Development.

• Auteurs principaux: Tiffany M Mott (Auteur), Sudhamathi Vijayakumar (Auteur), Elena Sbrana (Auteur), Janice J Endsley (Auteur), Alfredo G Torres (Auteur)
• Format: Livre
• Publié: Public Library of Science (PLoS), 2015-01-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

BACKGROUND:In this study, a Burkholderia mallei tonB mutant (TMM001) deficient in iron acquisition was constructed, characterized, and evaluated for its protective properties in acute inhalational infection models of murine glanders and melioidosis. METHODOLOGY/PRINCIPAL FINDINGS:Compared to the wil...