Epigenetic targets of Janus kinase inhibitors are linked to genetic risks of rheumatoid arthritis

• Main Authors: Haruka Tsuchiya (Author), Mineto Ota (Author), Haruka Takahashi (Author), Hiroaki Hatano (Author), Megumi Ogawa (Author), Sotaro Nakajima (Author), Risa Yoshihara (Author), Tomohisa Okamura (Author), Shuji Sumitomo (Author), Keishi Fujio (Author)
• Format: Book
• Published: BMC, 2024-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Current strategies that target cytokines (e.g., tumor necrosis factor (TNF)-α), or signaling molecules (e.g., Janus kinase (JAK)) have advanced the management for allergies and autoimmune diseases. Nevertheless, the molecular mechanism that underpins its clinical efficacy have la...