Epigenetic targets of Janus kinase inhibitors are linked to genetic risks of rheumatoid arthritis

• Glavni autori: Haruka Tsuchiya (Autor), Mineto Ota (Autor), Haruka Takahashi (Autor), Hiroaki Hatano (Autor), Megumi Ogawa (Autor), Sotaro Nakajima (Autor), Risa Yoshihara (Autor), Tomohisa Okamura (Autor), Shuji Sumitomo (Autor), Keishi Fujio (Autor)
• Format: Knjiga
• Izdano: BMC, 2024-06-01T00:00:00Z.
• Teme: article
• Online pristup: Connect to this object online.

Abstract Background Current strategies that target cytokines (e.g., tumor necrosis factor (TNF)-α), or signaling molecules (e.g., Janus kinase (JAK)) have advanced the management for allergies and autoimmune diseases. Nevertheless, the molecular mechanism that underpins its clinical efficacy have la...