A 2D-QSPR approach to predict blood-brain barrier penetration of drugs acting on the central nervous system
Drugs acting on the central nervous system (CNS) have to cross the blood-brain barrier (BBB) in order to perform their pharmacological actions. Passive BBB diffusion can be partially expressed by the blood/brain partition coefficient (logBB). As the experimental evaluation of logBB is time and cost...
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Format: | Book |
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Universidade de São Paulo,
2010-12-01T00:00:00Z.
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A1234.567 |
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Copy 1 | Available |