A 2D-QSPR approach to predict blood-brain barrier penetration of drugs acting on the central nervous system

Drugs acting on the central nervous system (CNS) have to cross the blood-brain barrier (BBB) in order to perform their pharmacological actions. Passive BBB diffusion can be partially expressed by the blood/brain partition coefficient (logBB). As the experimental evaluation of logBB is time and cost...

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Main Authors: Matheus Malta de Sá (Author), Kerly Fernanda Mesquita Pasqualoto (Author), Carlota de Oliveira Rangel-Yagui (Author)
Format: Book
Published: Universidade de São Paulo, 2010-12-01T00:00:00Z.
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3rd Floor Main Library

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Call Number: A1234.567
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