A 2D-QSPR approach to predict blood-brain barrier penetration of drugs acting on the central nervous system

• Main Authors: Matheus Malta de Sá (Author), Kerly Fernanda Mesquita Pasqualoto (Author), Carlota de Oliveira Rangel-Yagui (Author)
• 格式: 圖書
• 出版: Universidade de São Paulo, 2010-12-01T00:00:00Z.
• 主題: article
• 在線閱讀: Connect to this object online.

Drugs acting on the central nervous system (CNS) have to cross the blood-brain barrier (BBB) in order to perform their pharmacological actions. Passive BBB diffusion can be partially expressed by the blood/brain partition coefficient (logBB). As the experimental evaluation of logBB is time and cost...