Inhibition of pro-inflammatory signaling in human primary macrophages by enhancing arginase-2 via target site blockers

• Главные авторы: Stephen Fitzsimons (Автор), María Muñoz-San Martín (Автор), Frances Nally (Автор), Eugene Dillon (Автор), Ifeolutembi A. Fashina (Автор), Moritz J. Strowitzki (Автор), Lluís Ramió-Torrentà (Автор), Jennifer K. Dowling (Автор), Chiara De Santi (Автор), Claire E. McCoy (Автор)
• Формат: ‌
• Опубликовано: Elsevier, 2023-09-01T00:00:00Z.
• Предметы: article
• Online-ссылка: Connect to this object online.

The modulation of macrophage phenotype from a pro-inflammatory to an anti-inflammatory state holds therapeutic potential in the treatment of inflammatory disease. We have previously shown that arginase-2 (Arg2), a mitochondrial enzyme, is a key regulator of the macrophage anti-inflammatory response....