Inhibition of pro-inflammatory signaling in human primary macrophages by enhancing arginase-2 via target site blockers

• Hoofdauteurs: Stephen Fitzsimons (Auteur), María Muñoz-San Martín (Auteur), Frances Nally (Auteur), Eugene Dillon (Auteur), Ifeolutembi A. Fashina (Auteur), Moritz J. Strowitzki (Auteur), Lluís Ramió-Torrentà (Auteur), Jennifer K. Dowling (Auteur), Chiara De Santi (Auteur), Claire E. McCoy (Auteur)
• Formaat: Boek
• Gepubliceerd in: Elsevier, 2023-09-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

The modulation of macrophage phenotype from a pro-inflammatory to an anti-inflammatory state holds therapeutic potential in the treatment of inflammatory disease. We have previously shown that arginase-2 (Arg2), a mitochondrial enzyme, is a key regulator of the macrophage anti-inflammatory response....