Inhibition of pro-inflammatory signaling in human primary macrophages by enhancing arginase-2 via target site blockers

• Main Authors: Stephen Fitzsimons (Author), María Muñoz-San Martín (Author), Frances Nally (Author), Eugene Dillon (Author), Ifeolutembi A. Fashina (Author), Moritz J. Strowitzki (Author), Lluís Ramió-Torrentà (Author), Jennifer K. Dowling (Author), Chiara De Santi (Author), Claire E. McCoy (Author)
• Format: Book
• Published: Elsevier, 2023-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The modulation of macrophage phenotype from a pro-inflammatory to an anti-inflammatory state holds therapeutic potential in the treatment of inflammatory disease. We have previously shown that arginase-2 (Arg2), a mitochondrial enzyme, is a key regulator of the macrophage anti-inflammatory response....