miR-34a/DRP-1-mediated mitophagy participated in cisplatin-induced ototoxicity via increasing oxidative stress

• Автори: Haiyan Wang (Автор), Hanqing Lin (Автор), Weibiao Kang (Автор), Lingfei Huang (Автор), Sisi Gong (Автор), Tao Zhang (Автор), Xiaotong Huang (Автор), Feinan He (Автор), Yongyi Ye (Автор), Yiyang Tang (Автор), Haiying Jia (Автор), Haidi Yang (Автор)
• Формат: Книга
• Опубліковано: BMC, 2023-03-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

Abstract Purpose Cisplatin is a widely used and effective chemotherapeutic agent for most solid malignant tumors. However, cisplatin-induced ototoxicity is a common adverse effect that limits the therapeutic efficacy of tumors in the clinic. To date, the specific mechanism of ototoxicity has not bee...