miR-34a/DRP-1-mediated mitophagy participated in cisplatin-induced ototoxicity via increasing oxidative stress

• मुख्य लेखकों: Haiyan Wang (लेखक), Hanqing Lin (लेखक), Weibiao Kang (लेखक), Lingfei Huang (लेखक), Sisi Gong (लेखक), Tao Zhang (लेखक), Xiaotong Huang (लेखक), Feinan He (लेखक), Yongyi Ye (लेखक), Yiyang Tang (लेखक), Haiying Jia (लेखक), Haidi Yang (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: BMC, 2023-03-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Abstract Purpose Cisplatin is a widely used and effective chemotherapeutic agent for most solid malignant tumors. However, cisplatin-induced ototoxicity is a common adverse effect that limits the therapeutic efficacy of tumors in the clinic. To date, the specific mechanism of ototoxicity has not bee...