miR-34a/DRP-1-mediated mitophagy participated in cisplatin-induced ototoxicity via increasing oxidative stress

• Main Authors: Haiyan Wang (Author), Hanqing Lin (Author), Weibiao Kang (Author), Lingfei Huang (Author), Sisi Gong (Author), Tao Zhang (Author), Xiaotong Huang (Author), Feinan He (Author), Yongyi Ye (Author), Yiyang Tang (Author), Haiying Jia (Author), Haidi Yang (Author)
• Format: Book
• Published: BMC, 2023-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Purpose Cisplatin is a widely used and effective chemotherapeutic agent for most solid malignant tumors. However, cisplatin-induced ototoxicity is a common adverse effect that limits the therapeutic efficacy of tumors in the clinic. To date, the specific mechanism of ototoxicity has not bee...