Quercetin prevents primordial follicle loss via suppression of PI3K/Akt/Foxo3a pathway activation in cyclophosphamide-treated mice

• Ngā kaituhi matua: Jianghui Li (Author), Hui Long (Author), Yanyan Cong (Author), Hongyuan Gao (Author), Qifeng Lyu (Author), Sha Yu (Author), Yanping Kuang (Author)
• Hōputu: Pukapuka
• I whakaputaina: BMC, 2021-04-01T00:00:00Z.
• Ngā marau: article
• Urunga tuihono: Connect to this object online.

Abstract Background Chemotherapy improves the survival rates of patients with various cancers but often causes some adverse effects, including ovarian damage, characterised by a decrease in primordial follicle stockpiles. Recent studies have revealed that chemotherapy may stimulate the PI3K signalli...