Multiple circulating alkaloids and saponins from intravenous Kang-Ai injection inhibit human cytochrome P450 and UDP-glucuronosyltransferase isozymes: potential drug-drug interactions

• Главные авторы: Zifei Qin (Автор), Mengmeng Jia (Автор), Jing Yang (Автор), Han Xing (Автор), Zhao Yin (Автор), Zhihong Yao (Автор), Xiaojian Zhang (Автор), Xinsheng Yao (Автор)
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• Опубликовано: BMC, 2020-07-01T00:00:00Z.
• Предметы: article
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Abstract Background Kang-Ai injection is widely used as an adjuvant therapy drug for many cancers, leukopenia, and chronic hepatitis B. Circulating alkaloids and saponins are believed to be responsible for therapeutic effects. However, their pharmacokinetics (PK) and excretion in vivo and the risk o...