Multiple circulating alkaloids and saponins from intravenous Kang-Ai injection inhibit human cytochrome P450 and UDP-glucuronosyltransferase isozymes: potential drug-drug interactions

• मुख्य लेखकों: Zifei Qin (लेखक), Mengmeng Jia (लेखक), Jing Yang (लेखक), Han Xing (लेखक), Zhao Yin (लेखक), Zhihong Yao (लेखक), Xiaojian Zhang (लेखक), Xinsheng Yao (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: BMC, 2020-07-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Abstract Background Kang-Ai injection is widely used as an adjuvant therapy drug for many cancers, leukopenia, and chronic hepatitis B. Circulating alkaloids and saponins are believed to be responsible for therapeutic effects. However, their pharmacokinetics (PK) and excretion in vivo and the risk o...