Thrombin induces a temporal biphasic vascular response through the differential phosphorylation of endothelial nitric oxide synthase via protease-activated receptor-1 and protein kinase C

• Главные авторы: Akihiro Okamura (Автор), Junichiro Miake (Автор), Takuya Tomomori (Автор), Aiko Takami (Автор), Tatsuya Sawano (Автор), Masaru Kato (Автор), Kazuyoshi Ogura (Автор), Daiki Tsujimoto (Автор), Shunsuke Kawatani (Автор), Kurniawan Priyono Agung (Автор), Tomomi Notsu (Автор), Ichiro Hisatome (Автор), Kazuhiro Yamamoto (Автор), Takeshi Imamura (Автор)
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• Опубликовано: Elsevier, 2022-04-01T00:00:00Z.
• Предметы: article
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Endothelial nitric oxide synthase (eNOS) is a critical regulatory enzyme that controls vascular tone via the production of nitric oxide. Although thrombin also modulates vascular tone predominantly via the activation of protease-activated receptors (PARs), the time course and mechanisms involved in...