Thrombin induces a temporal biphasic vascular response through the differential phosphorylation of endothelial nitric oxide synthase via protease-activated receptor-1 and protein kinase C

• Main Authors: Akihiro Okamura (Author), Junichiro Miake (Author), Takuya Tomomori (Author), Aiko Takami (Author), Tatsuya Sawano (Author), Masaru Kato (Author), Kazuyoshi Ogura (Author), Daiki Tsujimoto (Author), Shunsuke Kawatani (Author), Kurniawan Priyono Agung (Author), Tomomi Notsu (Author), Ichiro Hisatome (Author), Kazuhiro Yamamoto (Author), Takeshi Imamura (Author)
• Format: Book
• Published: Elsevier, 2022-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Endothelial nitric oxide synthase (eNOS) is a critical regulatory enzyme that controls vascular tone via the production of nitric oxide. Although thrombin also modulates vascular tone predominantly via the activation of protease-activated receptors (PARs), the time course and mechanisms involved in...