Anorectic and aversive effects of GLP-1 receptor agonism are mediated by brainstem cholecystokinin neurons, and modulated by GIP receptor activation

• Main Authors: Alessia Costa (Author), Minrong Ai (Author), Nicolas Nunn (Author), Isabella Culotta (Author), Jenna Hunter (Author), Mehdi Boutagouga Boudjadja (Author), Lourdes Valencia-Torres (Author), Gabriella Aviello (Author), David J. Hodson (Author), Brandy M. Snider (Author), Tamer Coskun (Author), Paul J. Emmerson (Author), Simon M. Luckman (Author), Giuseppe D'Agostino (Author)
• Format: Book
• Published: Elsevier, 2022-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are effective medications to reduce appetite and body weight. These actions are centrally mediated; however, the neuronal substrates involved are poorly understood. Methods: We employed a combination of neuroanatomical, genetic, and beh...