Anorectic and aversive effects of GLP-1 receptor agonism are mediated by brainstem cholecystokinin neurons, and modulated by GIP receptor activation

• मुख्य लेखकों: Alessia Costa (लेखक), Minrong Ai (लेखक), Nicolas Nunn (लेखक), Isabella Culotta (लेखक), Jenna Hunter (लेखक), Mehdi Boutagouga Boudjadja (लेखक), Lourdes Valencia-Torres (लेखक), Gabriella Aviello (लेखक), David J. Hodson (लेखक), Brandy M. Snider (लेखक), Tamer Coskun (लेखक), Paul J. Emmerson (लेखक), Simon M. Luckman (लेखक), Giuseppe D'Agostino (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Elsevier, 2022-01-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Objective: Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are effective medications to reduce appetite and body weight. These actions are centrally mediated; however, the neuronal substrates involved are poorly understood. Methods: We employed a combination of neuroanatomical, genetic, and beh...