Anorectic and aversive effects of GLP-1 receptor agonism are mediated by brainstem cholecystokinin neurons, and modulated by GIP receptor activation

• المؤلفون الرئيسيون: Alessia Costa (مؤلف), Minrong Ai (مؤلف), Nicolas Nunn (مؤلف), Isabella Culotta (مؤلف), Jenna Hunter (مؤلف), Mehdi Boutagouga Boudjadja (مؤلف), Lourdes Valencia-Torres (مؤلف), Gabriella Aviello (مؤلف), David J. Hodson (مؤلف), Brandy M. Snider (مؤلف), Tamer Coskun (مؤلف), Paul J. Emmerson (مؤلف), Simon M. Luckman (مؤلف), Giuseppe D'Agostino (مؤلف)
• التنسيق: كتاب
• منشور في: Elsevier, 2022-01-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

Objective: Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are effective medications to reduce appetite and body weight. These actions are centrally mediated; however, the neuronal substrates involved are poorly understood. Methods: We employed a combination of neuroanatomical, genetic, and beh...