Enhanced Solubility, Permeability and Anticancer Activity of Vorinostat Using Tailored Mesoporous Silica Nanoparticles

• Asıl Yazarlar: Anand Kumar Meka (Yazar), Laura J. Jenkins (Yazar), Mercedes Dàvalos-Salas (Yazar), Naisarg Pujara (Yazar), Kuan Yau Wong (Yazar), Tushar Kumeria (Yazar), John M. Mariadason (Yazar), Amirali Popat (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: MDPI AG, 2018-12-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

Suberoylanilide hydroxamic acid (SAHA) or vorinostat (VOR) is a potent inhibitor of class I histone deacetylases (HDACs) that is approved for the treatment of cutaneous T-cell lymphoma. However, it has the intrinsic limitations of low water solubility and low permeability which reduces its clinical...