Enhanced Solubility, Permeability and Anticancer Activity of Vorinostat Using Tailored Mesoporous Silica Nanoparticles

• मुख्य लेखकों: Anand Kumar Meka (लेखक), Laura J. Jenkins (लेखक), Mercedes Dàvalos-Salas (लेखक), Naisarg Pujara (लेखक), Kuan Yau Wong (लेखक), Tushar Kumeria (लेखक), John M. Mariadason (लेखक), Amirali Popat (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: MDPI AG, 2018-12-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Suberoylanilide hydroxamic acid (SAHA) or vorinostat (VOR) is a potent inhibitor of class I histone deacetylases (HDACs) that is approved for the treatment of cutaneous T-cell lymphoma. However, it has the intrinsic limitations of low water solubility and low permeability which reduces its clinical...