Enhanced Solubility, Permeability and Anticancer Activity of Vorinostat Using Tailored Mesoporous Silica Nanoparticles

• Main Authors: Anand Kumar Meka (Author), Laura J. Jenkins (Author), Mercedes Dàvalos-Salas (Author), Naisarg Pujara (Author), Kuan Yau Wong (Author), Tushar Kumeria (Author), John M. Mariadason (Author), Amirali Popat (Author)
• Format: Book
• Published: MDPI AG, 2018-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Suberoylanilide hydroxamic acid (SAHA) or vorinostat (VOR) is a potent inhibitor of class I histone deacetylases (HDACs) that is approved for the treatment of cutaneous T-cell lymphoma. However, it has the intrinsic limitations of low water solubility and low permeability which reduces its clinical...