Enhanced Solubility, Permeability and Anticancer Activity of Vorinostat Using Tailored Mesoporous Silica Nanoparticles

• Hoofdauteurs: Anand Kumar Meka (Auteur), Laura J. Jenkins (Auteur), Mercedes Dàvalos-Salas (Auteur), Naisarg Pujara (Auteur), Kuan Yau Wong (Auteur), Tushar Kumeria (Auteur), John M. Mariadason (Auteur), Amirali Popat (Auteur)
• Formaat: Boek
• Gepubliceerd in: MDPI AG, 2018-12-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

Suberoylanilide hydroxamic acid (SAHA) or vorinostat (VOR) is a potent inhibitor of class I histone deacetylases (HDACs) that is approved for the treatment of cutaneous T-cell lymphoma. However, it has the intrinsic limitations of low water solubility and low permeability which reduces its clinical...