The Current State and Future of CRISPR-Cas9 gRNA Design Tools

• Egile Nagusiak: Laurence O. W. Wilson (Egilea), Aidan R. O'Brien (Egilea), Denis C. Bauer (Egilea)
• Formatua: Liburua
• Argitaratua: Frontiers Media S.A., 2018-07-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Recent years have seen the development of computational tools to assist researchers in performing CRISPR-Cas9 experiment optimally. More specifically, these tools aim to maximize on-target activity (guide efficiency) while also minimizing potential off-target effects (guide specificity) by analyzing...