SPAK and OSR1 Dependent Down-Regulation of Murine Renal Outer Medullary K+ Channel ROMK1

• Główni autorzy: Bernat Elvira (Autor), Carlos Munoz (Autor), Jose Borras (Autor), Hong Chen (Autor), Jamshed Warsi (Autor), Sumant Singh Ajay (Autor), Ekaterina Shumilina (Autor), Florian Lang (Autor)
• Format: Książka
• Wydane: Karger Publishers, 2014-09-01T00:00:00Z.
• Hasła przedmiotowe: article
• Dostęp online: Connect to this object online.

Background/Aims: The kinases SPAK (SPS1-related proline/alanine-rich kinase) and OSR1 (oxidative stress-responsive kinase 1) participate in the regulation of the NaCl cotransporter NCC and the Na+,K+,2Cl- cotransporter NKCC2. The kinases are regulated by WNK (with-no-K[Lys]) kinases. Mutations of ge...