SPAK and OSR1 Dependent Down-Regulation of Murine Renal Outer Medullary K+ Channel ROMK1

• Main Authors: Bernat Elvira (Author), Carlos Munoz (Author), Jose Borras (Author), Hong Chen (Author), Jamshed Warsi (Author), Sumant Singh Ajay (Author), Ekaterina Shumilina (Author), Florian Lang (Author)
• Format: Book
• Published: Karger Publishers, 2014-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background/Aims: The kinases SPAK (SPS1-related proline/alanine-rich kinase) and OSR1 (oxidative stress-responsive kinase 1) participate in the regulation of the NaCl cotransporter NCC and the Na+,K+,2Cl- cotransporter NKCC2. The kinases are regulated by WNK (with-no-K[Lys]) kinases. Mutations of ge...