25-Hydroxyvitamin D3 1-Alpha-Hydroxylase-Dependent Stimulation of Renal Klotho Expression by Spironolactone

25-Hydroxyvitamin D3 1-Alpha-Hydroxylase-Dependent Stimulation of Renal Klotho Expression by Spironolactone

Background: Klotho, a transmembrane protein, protease and hormone mainly expressed in kidney, is required for the suppression of 1,25(OH)2D3-generating 25-hydroxyvitamin D3 1-alpha-hydroxylase (Cyp27b1) by FGF23. Conversely, 1,25(OH)2D3 stimulates, by activating the vitamin D3 receptor (Vdr), the ex...

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Main Authors: Ioana Alesutan (Author), Martina Feger (Author), Tatsiana Pakladok (Author), Sobuj Mia (Author), Mohamed Siyabeldin E. Ahmed (Author), Jakob Voelkl (Author), Florian Lang (Author)
Format: Book
Published: Karger Publishers, 2013-11-01T00:00:00Z.
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3rd Floor Main Library

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