25-Hydroxyvitamin D3 1-Alpha-Hydroxylase-Dependent Stimulation of Renal Klotho Expression by Spironolactone

• मुख्य लेखकों: Ioana Alesutan (लेखक), Martina Feger (लेखक), Tatsiana Pakladok (लेखक), Sobuj Mia (लेखक), Mohamed Siyabeldin E. Ahmed (लेखक), Jakob Voelkl (लेखक), Florian Lang (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Karger Publishers, 2013-11-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Background: Klotho, a transmembrane protein, protease and hormone mainly expressed in kidney, is required for the suppression of 1,25(OH)2D3-generating 25-hydroxyvitamin D3 1-alpha-hydroxylase (Cyp27b1) by FGF23. Conversely, 1,25(OH)2D3 stimulates, by activating the vitamin D3 receptor (Vdr), the ex...