Nanonization and Deformable Behavior of Fattigated Peptide Drug in Mucoadhesive Buccal Films

• Main Authors: Woojun Kim (Author), Hai V. Ngo (Author), Hy D. Nguyen (Author), Ji-Min Park (Author), Kye Wan Lee (Author), Chulhun Park (Author), Jun-Bom Park (Author), Beom-Jin Lee (Author)
• Format: Book
• Published: MDPI AG, 2024-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

This study was tasked with the design of mucoadhesive buccal films (MBFs) containing a peptide drug, leuprolide (LEU), or its diverse nanoparticles (NPs), for enhanced membrane permeability via self-assembled nanonization and deformable behavior. An LEU-oleic acid conjugate (LOC) and its self-assemb...