PTHG2 Reduces Bone Loss in Ovariectomized Mice by Directing Bone Marrow Mesenchymal Stem Cell Fate

• Main Authors: Jiao Chen (Author), Hao Zhang (Author), Xianmin Wu (Author), Fuxiao Wang (Author), Yili Wang (Author), Qianmin Gao (Author), Han Liu (Author), Yan Hu (Author), Jiacan Su (Author), Yingying Jing (Author)
• Format: Book
• Published: Hindawi Limited, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Teriparatide, also known as 1-34 parathyroid hormone (PTH (1-34)), is commonly used for the treatment of osteoporosis in postmenopausal women. But its therapeutic application is restricted by poor metabolic stability, low bioavailability, and rapid clearance. Herein, PTHG2, a glycosylated teriparati...