Thiopurine S-methyltransferase and Pemphigus Vulgaris: A Phenotype-Genotype Study

• Glavni autori: Maral Mokhtari (Autor), Farzaneh Mostanbet (Autor), Saideh Nekooee Fard (Autor), Golsa Shekarkhar (Autor), Mozhdeh Sepaskhah (Autor), Maryam Sadat Sadati (Autor)
• Format: Knjiga
• Izdano: Iranian Society of Pathology, 2020-10-01T00:00:00Z.
• Teme: article
• Online pristup: Connect to this object online.

Background & Objective:  Thiopurine drugs are considered as a treatment modality in various autoimmune disorders including pemphigus vulgaris (PV). These drugs are metabolized by an enzyme "Thiopurine S-methyl transferase" (TPMT). Various variants of this enzyme may have decreased acti...