Thiopurine S-methyltransferase and Pemphigus Vulgaris: A Phenotype-Genotype Study

• Главные авторы: Maral Mokhtari (Автор), Farzaneh Mostanbet (Автор), Saideh Nekooee Fard (Автор), Golsa Shekarkhar (Автор), Mozhdeh Sepaskhah (Автор), Maryam Sadat Sadati (Автор)
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• Опубликовано: Iranian Society of Pathology, 2020-10-01T00:00:00Z.
• Предметы: article
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Background & Objective:  Thiopurine drugs are considered as a treatment modality in various autoimmune disorders including pemphigus vulgaris (PV). These drugs are metabolized by an enzyme "Thiopurine S-methyl transferase" (TPMT). Various variants of this enzyme may have decreased acti...