Heterogeneity in clone dynamics within and adjacent to intestinal tumours identified by Dre-mediated lineage tracing

• Main Authors: Ann-Sofie Thorsen (Author), Doran Khamis (Author), Richard Kemp (Author), Mathilde Colombé (Author), Filipe C. Lourenço (Author), Edward Morrissey (Author), Douglas Winton (Author)
• Format: Book
• Published: The Company of Biologists, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Somatic models of tissue pathology commonly use induction of gene-specific mutations in mice mediated by spatiotemporal regulation of Cre recombinase. Subsequent investigation of the onset and development of disease can be limited by the inability to track changing cellular behaviours over time. Her...