Heterogeneity in clone dynamics within and adjacent to intestinal tumours identified by Dre-mediated lineage tracing

• Κύριοι συγγραφείς: Ann-Sofie Thorsen (Συγγραφέας), Doran Khamis (Συγγραφέας), Richard Kemp (Συγγραφέας), Mathilde Colombé (Συγγραφέας), Filipe C. Lourenço (Συγγραφέας), Edward Morrissey (Συγγραφέας), Douglas Winton (Συγγραφέας)
• Μορφή: Βιβλίο
• Έκδοση: The Company of Biologists, 2021-01-01T00:00:00Z.
• Θέματα: article
• Διαθέσιμο Online: Connect to this object online.

Somatic models of tissue pathology commonly use induction of gene-specific mutations in mice mediated by spatiotemporal regulation of Cre recombinase. Subsequent investigation of the onset and development of disease can be limited by the inability to track changing cellular behaviours over time. Her...