Pharmacokinetic Parameters of Quinine in Healthy Subjects and in Patients with Uncomplicated Malaria in Nigeria: Analysis of Data using a Population Approach

• Main Authors: Ayorinde Adehin, PhD (Author), Sharon I. Igbinoba, PhD (Author), Julius O. Soyinka, PhD (Author), Cyprian O. Onyeji, PhD (Author), Chinedum P. Babalola, PhD (Author), Oluseye O. Bolaji, PhD (Author)
• Format: Book
• Published: Elsevier, 2019-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

ABSTRACT: Background: The varied disposition of the antimalarial quinine partly explains its poor tolerance and toxicity in humans. Objective: Using a population approach, the disposition of quinine in healthy subjects and patients with acute uncomplicated symptomatic malaria from Nigeria was re-exa...