Pioglitazone Ameliorates Hippocampal Neurodegeneration, Disturbances in Glucose Metabolism and AKT/mTOR Signaling Pathways in Pentyelenetetrazole-Kindled Mice

• Autori principali: Nada El-Megiri (Autore), Yasser M. Mostafa (Autore), Amal Ahmed (Autore), Eman T. Mehanna (Autore), Mona F. El-Azab (Autore), Fatma Alshehri (Autore), Hadil Alahdal (Autore), Norhan M. El-Sayed (Autore)
• Natura: Libro
• Pubblicazione: MDPI AG, 2022-09-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

Disturbance of glucose metabolism, nerve growth factor (NGF) and m-TOR signaling have been associated with the pathophysiology of epilepsy. Pioglitazone (PGZ) is an anti-diabetic drug that shows a protective effect in neurodegenerative diseases including epilepsy; however, its exact mechanism is not...