Pioglitazone Ameliorates Hippocampal Neurodegeneration, Disturbances in Glucose Metabolism and AKT/mTOR Signaling Pathways in Pentyelenetetrazole-Kindled Mice

• Main Authors: Nada El-Megiri (Author), Yasser M. Mostafa (Author), Amal Ahmed (Author), Eman T. Mehanna (Author), Mona F. El-Azab (Author), Fatma Alshehri (Author), Hadil Alahdal (Author), Norhan M. El-Sayed (Author)
• Format: Book
• Published: MDPI AG, 2022-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Disturbance of glucose metabolism, nerve growth factor (NGF) and m-TOR signaling have been associated with the pathophysiology of epilepsy. Pioglitazone (PGZ) is an anti-diabetic drug that shows a protective effect in neurodegenerative diseases including epilepsy; however, its exact mechanism is not...