Pioglitazone Ameliorates Hippocampal Neurodegeneration, Disturbances in Glucose Metabolism and AKT/mTOR Signaling Pathways in Pentyelenetetrazole-Kindled Mice

• Auteurs principaux: Nada El-Megiri (Auteur), Yasser M. Mostafa (Auteur), Amal Ahmed (Auteur), Eman T. Mehanna (Auteur), Mona F. El-Azab (Auteur), Fatma Alshehri (Auteur), Hadil Alahdal (Auteur), Norhan M. El-Sayed (Auteur)
• Format: Livre
• Publié: MDPI AG, 2022-09-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

Disturbance of glucose metabolism, nerve growth factor (NGF) and m-TOR signaling have been associated with the pathophysiology of epilepsy. Pioglitazone (PGZ) is an anti-diabetic drug that shows a protective effect in neurodegenerative diseases including epilepsy; however, its exact mechanism is not...