Pharmacokinetic-pharmacodynamic correlation of imipenem in pediatric burn patients using a bioanalytical liquid chromatographic method

• Autori principali: Silvia Regina Cavani Jorge Santos (Autore), Cristina Sanches-Giraud (Autore), Carlindo Vieira Silva Júnior (Autore), David Souza Gomez (Autore)
• Natura: Libro
• Pubblicazione: Universidade de São Paulo, 2015-06-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

<p>A bioanalytical method was developed and applied to quantify the free imipenem concentrations for pharmacokinetics and PK/PD correlation studies of the dose adjustments required to maintain antimicrobial effectiveness in pediatric burn patients. A reverse-phase Supelcosil LC18 column (250 x...