Guidance on Selecting Optimal Steady-State Tacrolimus Concentrations for Continuous IV Perfusion: Insights from Physiologically Based Pharmacokinetic Modeling

• Главные авторы: Romain Martischang (Автор), Argyro Nikolaou (Автор), Youssef Daali (Автор), Caroline Flora Samer (Автор), Jean Terrier (Автор)
• Формат: ‌
• Опубликовано: MDPI AG, 2024-08-01T00:00:00Z.
• Предметы: article
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<b>Introduction</b>: The dose-response relationships of tacrolimus have been primarily assessed through trough concentrations during intermittent administrations. In scenarios where oral administration (PO) is unfeasible, continuous intravenous (IV) administration is advised. Under these...