Methotrexate causes acute hyperplasia of enterochromaffin cells containing substance P in the intestinal mucosa of rats

• Κύριοι συγγραφείς: Takuji Machida (Συγγραφέας), Yuho Takano (Συγγραφέας), Kenji Iizuka (Συγγραφέας), Maiko Machida (Συγγραφέας), Masahiko Hirafuji (Συγγραφέας)
• Μορφή: Βιβλίο
• Έκδοση: Elsevier, 2017-03-01T00:00:00Z.
• Θέματα: article
• Διαθέσιμο Online: Connect to this object online.

This study aimed to investigate the acute and chronic effect of methotrexate on the intestinal substance P metabolism after a single administration to rats. Methotrexate caused a significant increase in the number of substance P-containing cells in the ileal mucosa both at 24 and 96 h. Most of enter...