Methotrexate causes acute hyperplasia of enterochromaffin cells containing substance P in the intestinal mucosa of rats

• প্রধান লেখক: Takuji Machida (লেখক), Yuho Takano (লেখক), Kenji Iizuka (লেখক), Maiko Machida (লেখক), Masahiko Hirafuji (লেখক)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: Elsevier, 2017-03-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

This study aimed to investigate the acute and chronic effect of methotrexate on the intestinal substance P metabolism after a single administration to rats. Methotrexate caused a significant increase in the number of substance P-containing cells in the ileal mucosa both at 24 and 96 h. Most of enter...