Synthesis and Structure Determination of Substituted Thiazole Derivatives as EGFR/BRAF<sup>V600E</sup> Dual Inhibitors Endowed with Antiproliferative Activity

Synthesis and Structure Determination of Substituted Thiazole Derivatives as EGFR/BRAF<sup>V600E</sup> Dual Inhibitors Endowed with Antiproliferative Activity

2,3,4-trisubstituted thiazoles <b>3a</b>-<b>i</b>, having a methyl group in position four, were synthesized by the reaction of 1,4-disubstituted thiosemicarbazides with chloroacetone in ethyl acetate/Et<sub>3</sub>N at room temperature or in ethanol under reflux....

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Main Authors: Lamya H. Al-Wahaibi (Author), Essmat M. El-Sheref (Author), Alaa A. Hassan (Author), S. Bräse (Author), M. Nieger (Author), Bahaa G. M. Youssif (Author), Mahmoud A. A. Ibrahim (Author), Hendawy N. Tawfeek (Author)
Format: Book
Published: MDPI AG, 2023-07-01T00:00:00Z.
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3rd Floor Main Library

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