Synthesis and Structure Determination of Substituted Thiazole Derivatives as EGFR/BRAF^V600E Dual Inhibitors Endowed with Antiproliferative Activity

• Autors principals: Lamya H. Al-Wahaibi (Autor), Essmat M. El-Sheref (Autor), Alaa A. Hassan (Autor), S. Bräse (Autor), M. Nieger (Autor), Bahaa G. M. Youssif (Autor), Mahmoud A. A. Ibrahim (Autor), Hendawy N. Tawfeek (Autor)
• Format: Llibre
• Publicat: MDPI AG, 2023-07-01T00:00:00Z.
• Matèries: article
• Accés en línia: Connect to this object online.

2,3,4-trisubstituted thiazoles <b>3a</b>-<b>i</b>, having a methyl group in position four, were synthesized by the reaction of 1,4-disubstituted thiosemicarbazides with chloroacetone in ethyl acetate/Et₃N at room temperature or in ethanol under reflux....