Dexmedetomidine Attenuates Lipopolysaccharide-Induced Sympathetic Activation and Sepsis via Suppressing Superoxide Signaling in Paraventricular Nucleus

• Autores principales: Jin-Hua Bo (Autor), Jing-Xiao Wang (Autor), Xiao-Li Wang (Autor), Yang Jiao (Autor), Ming Jiang (Autor), Jun-Liu Chen (Autor), Wen-Yuan Hao (Autor), Qi Chen (Autor), Yue-Hua Li (Autor), Zheng-Liang Ma (Autor), Guo-Qing Zhu (Autor)
• Formato: Libro
• Publicado: MDPI AG, 2022-12-01T00:00:00Z.
• Materias: article
• Acceso en línea: Connect to this object online.

Sympathetic overactivity contributes to the pathogenesis of sepsis. The selective α2-adrenergic receptor agonist dexmedetomidine (DEX) is widely used for perioperative sedation and analgesia. We aimed to determine the central roles and mechanisms of DEX in attenuating sympathetic activity and inflam...