Dexmedetomidine Attenuates Lipopolysaccharide-Induced Sympathetic Activation and Sepsis via Suppressing Superoxide Signaling in Paraventricular Nucleus

• Main Authors: Jin-Hua Bo (Author), Jing-Xiao Wang (Author), Xiao-Li Wang (Author), Yang Jiao (Author), Ming Jiang (Author), Jun-Liu Chen (Author), Wen-Yuan Hao (Author), Qi Chen (Author), Yue-Hua Li (Author), Zheng-Liang Ma (Author), Guo-Qing Zhu (Author)
• Format: Book
• Published: MDPI AG, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Sympathetic overactivity contributes to the pathogenesis of sepsis. The selective α2-adrenergic receptor agonist dexmedetomidine (DEX) is widely used for perioperative sedation and analgesia. We aimed to determine the central roles and mechanisms of DEX in attenuating sympathetic activity and inflam...