Characterization of Non-Specific Uptake and Retention Mechanisms of [¹⁷⁷Lu]Lu-PSMA-617 in the Salivary Glands

• Main Authors: Nathalie Heynickx (Author), Charlotte Segers (Author), Amelie Coolkens (Author), Sarah Baatout (Author), Koen Vermeulen (Author)
• Format: Book
• Published: MDPI AG, 2023-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The radionuclide therapy [¹⁷⁷Lu]Lu-PSMA-617 was recently FDA-approved for treatment of metastatic castration-resistant prostate cancer. Salivary gland toxicity is currently considered as the main dose-limiting side effect. However, its uptake and retention mechanisms in the sa...