A conditional RNA Pol II mono-promoter drives HIV-inducible, CRISPR-mediated cyclin T1 suppression and HIV inhibition

• المؤلفون الرئيسيون: Srinivasan Chinnapaiyan (مؤلف), Maria-Jose Santiago (مؤلف), Kingshuk Panda (مؤلف), Md. Sohanur Rahman (مؤلف), Jessica Alluin (مؤلف), John Rossi (مؤلف), Hoshang J. Unwalla (مؤلف)
• التنسيق: كتاب
• منشور في: Elsevier, 2023-06-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

Gene editing using clustered regularly interspaced short palindromic repeats (CRISPR) targeted to HIV proviral DNA has shown excision of HIV from infected cells. However, CRISPR-based HIV excision is vulnerable to viral escape. Targeting cellular co-factors provides an attractive yet risky alternati...