A conditional RNA Pol II mono-promoter drives HIV-inducible, CRISPR-mediated cyclin T1 suppression and HIV inhibition

• প্রধান লেখক: Srinivasan Chinnapaiyan (লেখক), Maria-Jose Santiago (লেখক), Kingshuk Panda (লেখক), Md. Sohanur Rahman (লেখক), Jessica Alluin (লেখক), John Rossi (লেখক), Hoshang J. Unwalla (লেখক)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: Elsevier, 2023-06-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

Gene editing using clustered regularly interspaced short palindromic repeats (CRISPR) targeted to HIV proviral DNA has shown excision of HIV from infected cells. However, CRISPR-based HIV excision is vulnerable to viral escape. Targeting cellular co-factors provides an attractive yet risky alternati...