A conditional RNA Pol II mono-promoter drives HIV-inducible, CRISPR-mediated cyclin T1 suppression and HIV inhibition

• Prif Awduron: Srinivasan Chinnapaiyan (Awdur), Maria-Jose Santiago (Awdur), Kingshuk Panda (Awdur), Md. Sohanur Rahman (Awdur), Jessica Alluin (Awdur), John Rossi (Awdur), Hoshang J. Unwalla (Awdur)
• Fformat: Llyfr
• Cyhoeddwyd: Elsevier, 2023-06-01T00:00:00Z.
• Pynciau: article
• Mynediad Ar-lein: Connect to this object online.

Gene editing using clustered regularly interspaced short palindromic repeats (CRISPR) targeted to HIV proviral DNA has shown excision of HIV from infected cells. However, CRISPR-based HIV excision is vulnerable to viral escape. Targeting cellular co-factors provides an attractive yet risky alternati...