A conditional RNA Pol II mono-promoter drives HIV-inducible, CRISPR-mediated cyclin T1 suppression and HIV inhibition

• Hauptverfasser: Srinivasan Chinnapaiyan (Verfasst von), Maria-Jose Santiago (Verfasst von), Kingshuk Panda (Verfasst von), Md. Sohanur Rahman (Verfasst von), Jessica Alluin (Verfasst von), John Rossi (Verfasst von), Hoshang J. Unwalla (Verfasst von)
• Format: Buch
• Veröffentlicht: Elsevier, 2023-06-01T00:00:00Z.
• Schlagworte: article
• Online-Zugang: Connect to this object online.

Gene editing using clustered regularly interspaced short palindromic repeats (CRISPR) targeted to HIV proviral DNA has shown excision of HIV from infected cells. However, CRISPR-based HIV excision is vulnerable to viral escape. Targeting cellular co-factors provides an attractive yet risky alternati...