A conditional RNA Pol II mono-promoter drives HIV-inducible, CRISPR-mediated cyclin T1 suppression and HIV inhibition

• Κύριοι συγγραφείς: Srinivasan Chinnapaiyan (Συγγραφέας), Maria-Jose Santiago (Συγγραφέας), Kingshuk Panda (Συγγραφέας), Md. Sohanur Rahman (Συγγραφέας), Jessica Alluin (Συγγραφέας), John Rossi (Συγγραφέας), Hoshang J. Unwalla (Συγγραφέας)
• Μορφή: Βιβλίο
• Έκδοση: Elsevier, 2023-06-01T00:00:00Z.
• Θέματα: article
• Διαθέσιμο Online: Connect to this object online.

Gene editing using clustered regularly interspaced short palindromic repeats (CRISPR) targeted to HIV proviral DNA has shown excision of HIV from infected cells. However, CRISPR-based HIV excision is vulnerable to viral escape. Targeting cellular co-factors provides an attractive yet risky alternati...